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Adults: Initially 25 mg (base) 2 times a day, with increases of 25-50 mg (base) 2 or 3 times daily to a target dosage range of 300-400 mg (base) a day, in divided doses given 2 or 3 times a day, by the 4th-7th day. Further dosage adjustments may be made in increments or decrements of 25-50 mg (base) 2 times a day at intervals of 2 days. Some patients may require as little as 150 mg a day.
Adult Prescribing Limits: 750 mg (base) a day.
Children: Antipsychotics safety and efficacy have not been established.
Note: A slower rate of dosage titration and a lower target dosage should be considered in geriatric patients and in patients with hepatic impairment, predisposition to hypotension, or other debilitation. A dose-response study did not find dosage of 300 mg (base) a day. When reinstituting quetiapine therapy in a patient who has discontinued quetiapine for >1 week, the initial titration schedule should be followed. If discontinuation has been for <1 week, quetiapine may be reinstituted at the previous maintenance dosage.
